2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118764
    Propargyl-PEG2-acid 1859379-85-3 98.0%
    Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-acid
  • HY-124480
    Tetrazine-Ph-acid 1380500-92-4 98.67%
    Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-acid
  • HY-120775
    Boc-NH-PEG1-CH2CH2COOH 1260092-44-1
    Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.
    Boc-NH-PEG1-CH2CH2COOH
  • HY-140585
    N-DBCO-N-bis(PEG2-C2-NHS ester) 2128735-29-3
    N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    N-DBCO-N-bis(PEG2-C2-NHS ester)
  • HY-21577
    Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 175724-30-8 98.0%
    Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
  • HY-140707
    m-PEG-thiol (MW 5000) 88778-21-6 99.90%
    m-PEG-thiol (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 5000)
  • HY-40152
    1-Boc-azetidine-3-yl-methanol 142253-56-3 99.99%
    1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
    1-Boc-azetidine-3-yl-methanol
  • HY-130481
    Propargyl-PEG4-acid 1415800-32-6
    Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-acid
  • HY-140679
    mPEG-amine (MW 20000) 80506-64-5
    m-PEG-NH2 (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-amine (MW 20000)
  • HY-140648
    Amine-PEG-amine (MW 5000)
    Amine-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG-amine (MW 5000)
  • HY-130551
    Tetrazine-Ph-PEG5-NHS ester 1682653-80-0 99.29%
    Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-PEG5-NHS ester
  • HY-42637
    N3-PEG3-CH2COOH 172531-37-2 99.84%
    N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N3-PEG3-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2COOH
  • HY-140227
    m-PEG12-amine 1977493-48-3 99.84%
    m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG12-amine
  • HY-141209
    Hydroxy-PEG3-CH2-Boc 518044-31-0
    Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-CH2-Boc
  • HY-W094307
    Methyl-PEG3-bromide 72593-77-2 98.23%
    Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl-PEG3-bromide
  • HY-141177
    TCO-PEG2-amine 2141981-87-3
    TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG2-amine
  • HY-126880
    Fmoc-NH-PEG8-NHS ester 1334170-03-4
    Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG8-NHS ester
  • HY-W013249
    Boc-piperazine-benzoic acid 162046-66-4
    Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229).
    Boc-piperazine-benzoic acid
  • HY-W017440
    Triethylene glycol 112-27-6 99.88%
    Triethylene glycol (PROTAC Linker 25) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Triethylene glycol
  • HY-134721
    Amine-PEG3-Desthiobiotin 2237234-71-6 99.87%
    Amine-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG3-Desthiobiotin
PROTAC Linkers Isoform Comparison

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