2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126974
    Propargyl-PEG3-NHS ester 1428629-71-3
    Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG3-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-NHS ester
  • HY-42151
    Mal-amido-PEG2-C2-acid 756525-98-1 99.80%
    Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-C2-acid
  • HY-W248248
    tert-Butyl 9-aminononanoate 134857-22-0 ≥98.0%
    tert-Butyl 9-aminononanoate is a PROTAC linker. tert-Butyl 9-aminononanoate can be used in synthesis PROTAC sEH-degrader-1 (HY-159494).
    tert-Butyl 9-aminononanoate
  • HY-116006
    Bis-PEG5-acid 439114-13-3 99.90%
    Bis-PEG5-acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis-PEG5-acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20.
    Bis-PEG5-acid
  • HY-130830
    m-PEG24-NHS ester 2395839-96-8 99.66%
    m-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-NHS ester
  • HY-130486
    NH2-PEG6-Boc 1286281-32-0 ≥98.0%
    NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG6-Boc
  • HY-40178
    NH2-C4-NH-Boc 68076-36-8 99.98%
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    NH2-C4-NH-Boc
  • HY-141366
    Bromo-PEG5-Boc 1415800-38-2
    Bromo-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG5-Boc
  • HY-120775
    Boc-NH-PEG1-CH2CH2COOH 1260092-44-1
    Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.
    Boc-NH-PEG1-CH2CH2COOH
  • HY-41921
    Propargyl-PEG3-alcohol 208827-90-1 99.40%
    Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-alcohol
  • HY-130512
    Br-PEG4-OH 85141-94-2 98.16%
    Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG4-OH
  • HY-W010975
    Fmoc-Lys-OH hydrochloride 139262-23-0 99.84%
    Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys-OH hydrochloride
  • HY-126959
    Biotin-PEG4-acid 721431-18-1
    Biotin-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG4-acid
  • HY-140707
    m-PEG-thiol (MW 5000) 88778-21-6 99.90%
    m-PEG-thiol (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 5000)
  • HY-130216
    THP-PEG3-OH 60221-37-6
    THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG3-OH
  • HY-141363
    Bromo-PEG4-acid 1393330-38-5 ≥98.0%
    Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG4-acid
  • HY-130147
    Propargyl-PEG5-OH 1036204-60-0
    Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-OH
  • HY-134704
    Biotin-PEG4-SH 2762393-22-4
    Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-SH
  • HY-W050087
    Octaethylene glycol 5117-19-1 99.97%
    Octaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Octaethylene glycol
  • HY-140070
    endo-BCN-PEG8-NHS ester 1608140-48-2
    endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG8-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG8-NHS ester
PROTAC Linkers Isoform Comparison

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